We welcome Julian in our group and wish him a lot of success and fun!

Our paper on rescuing reads as well as correcting reverse transcrition mediated bias in quantification of nucleotide conversion RNA-seq data is now published. Congrats Kevin for this really nice piece of work and thanks to all collaboration partners!

Link

Stefan joined our team in Regensburg. We wish him a lot of success and fun!

Our preprint on rescuing previously unmappable reads as well as correcting reverse transcrition mediated bias in quantification of nucleotide conversion RNA-seq data is on bioRxiv. Thanks Kevin for a major effort!

https://www.biorxiv.org/content/10.1101/2023.04.21.537786v1

We welcome Michael Lappe in our lab and wish him all the best for his research!

Our lab moved from the Institute for Virology and Immunobiology at the University of Würzburg at the new Faculty for Informatics and Data Science at the University of Regensburg. We are absolutely excited and look forward to all future challenges.

Collaboration with Cochain-lab: Integrated single-cell analysis-based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis

https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvac161/6747513?preview=true&itm_medium=sidebar&itm_source=trendmd-widget&itm_campaign=Cardiovascular_Research&itm_content=Cardiovascular_Research_0&login=true

Collaboration with Schlosser lab: Extending the Mass Spectrometry-Detectable Landscape of MHC Peptides by Use of Restricted Access Material

https://pubs.acs.org/doi/full/10.1021/acs.analchem.2c02198

Collaboration with Fischer lab: An unusual mode of baseline translation adjusts cellular protein synthesis capacity to metabolic needs

https://www.sciencedirect.com/science/article/pii/S2211124722013171

Collaboration with Dölken lab: Two murine cytomegalovirus microRNAs target the major viral immediate early 3 gene

https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001804

Collaboration with Dölken lab: pUL36 Deubiquitinase Activity Augments Both the Initiation and the Progression of Lytic Herpes Simplex Virus Infection in IFN-Primed Cells

https://journals.asm.org/doi/full/10.1128/jvi.00963-22

The combination of single-cell RNA sequencing (scRNA-seq) with metabolic RNA labelling approaches now enables time-resolved monitoring of transcriptional responses for thousands of genes in thousands of individual cells in parallel.

https://www.nature.com/articles/s43586-022-00157-z

A preprint on our grandR package is now on bioRxiv. It offers easy access to all different kind of downstream analysis for nucleotide conversion RNA-seq data (such as SLAM-seq or TUC-seq), and introduced new computational methodology for quality control and temporal recalibration as well as a Bayesian hierarchical model to analyze synthesis and degradation rates from single snapshot experiments as well as changes thereof. Thanks Teresa and Lygeri for a major effort!

https://www.biorxiv.org/content/10.1101/2022.09.12.507665v1

Kilian joined our group. We wish him a warm welcome a lot of success and fun!