Fantastic collaboration with the Wolf lab. Acute depletion of SPT6 analyzed with 4sU-seq, ChIP-seq, 4sUDRB-seq and SLAM-seq, including mathematical modeling and new computational concepts (LFC regression, DRB wave-front estimation / POL 2 termination zone decline via negative binomial regression, modeling transcriptional kinetics w/o steady-state using SLAM-seq)
https://authors.elsevier.com/sd/article/S1097-2765(21)00496-2
SLAM-seq and iCLIP identified the antiviral protein ZAP to bind and destabilize human cytomegalovirus UL4/5 transcripts. Very cool application of SLAM-seq to distinguish transcriptional regulation from RNA destabilization, and very nice collaboration with the Brinkmann lab and the Munschauer lab.
Our paper on iTiSS is now online: https://academic.oup.com/bioinformatics/advance-article-abstract/doi/10.1093/bioinformatics/btab170/6171178
Congrats, Chris!
We welcome Lygeri in our group and wish her a lot of success and fun!
We have a new lab member! We welcome Kevin and wish him a lot of success and fun!
Our paper on de novo peptide sequencing and improved identification of MHC-I (a.k.a.) HLA-I immunopeptidomes is finally published at Cancer Immunology Research. Very nice collaboration with the Schlosser-lab!
Our paper on re-annotating HSV-1 is finally accepted (another fantastic collaboration with the Dölken lab):
Pre-print: https://www.biorxiv.org/content/10.1101/603654v1
Nature Comm: https://www.nature.com/articles/s41467-020-15992-5
Congrats, Chris and Adam!
We have a new website!